.NET Client Profile is supported by .NET Ver. 3.5 and 4.0. It is designed for client applications like Windows Forms. Client Profile version of .NET Framework is lightweight subset of Framework. This enables quicker deployment and small installation packages. 
Web Application doesn’t support Client Profile version of the Framework.
Microsoft has removed Client Profile from latest version of .NET Framework 4.5 and hence with .NET 4.5 there is no Client Profile as shown in the image below.
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I am a hands-on architect with proven 19+ years of experience in architecting, designing, and developing distributed software solutions for large enterprises. At Microsoft, as a Principal Software Engineering Manager, I own the Platform team. I see software development as a craft, and I am a big proponent of software architecture and clean code discipline-n-practices. I like to see the bigger picture and make a broader impact. I was also a Microsoft MVP for past 7 years on Visual Studio and Dev Technologies I can be reached at vidya_mct@yahoo.com or twitter @dotnetauthor
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